Christopher R. Brown

Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation

This study shows that methamphetamine reduces DAT palmitoylation, linking this modification to transport down-regulation and suggesting its role in dopamine reuptake regulation.

Modulation of autism-associated serotonin transporters by palmitoylation: Insights into the molecular pathogenesis and targeted therapies for autism spectrum disorder

This study investigates how palmitoylation modulates autism-associated serotonin transporter variants and shows that escitalopram can normalize their function.

Palmitoylation regulates norepinephrine transporter trafficking and expression and is potentially involved in the pathogenesis of postural orthostatic tachycardia syndrome

This study shows that palmitoylation regulates norepinephrine transporter (NET) trafficking and expression, and that a POTS-associated NET mutant has reduced palmitoylation and surface expression.

Palmitoylation regulates human serotonin transporter activity, trafficking, and expression and is modulated by escitalopram

This study shows that palmitoylation regulates SERT activity, trafficking, and expression, and that escitalopram reduces SERT palmitoylation, leading to decreased surface expression and transport capacity.