Cryptococcus neoformans adapts to host CO2 concentrations through the coordinated remodeling of central carbon metabolism, oxidative stress resistance, and membrane homeostasis.
Laura C. Ristow, Edith Blackburn, Andrew J. Jezewski, Xiaorong Lin, Damian J. Krysan
This study identifies genetic determinants of CO2 tolerance in Cryptococcus neoformans through a genome-wide screen and shows it involves metabolic remodeling and stress response pathways.
bioRxiv · Nov 28, 2025 · PreprintMicrobiology