Hyperacetylated Chromatin Domains Mark Cell Type-Specific Genes and Suggest Distinct Modes of Enhancer Function
Sierra Fox, Jacquelyn Myers, Christina Davidson, Michael R. Getman, Paul D. Kingsley, Nicholas Frankiewicz, Michael Bulger
The paper introduces hyperacetylated chromatin domains (HCDs) as a method to identify cell type-specific genes, finding they outperform super-enhancers in expression and cell identity alignment.
Nature Communications · Sep 11, 2020Peer-reviewedGenetics