Contingencies in biofilm adaptation of Mycobacterium tuberculosis
John F. Kernien, Madison A. Youngblom, Tracy M. Smith, Sydney S Fry, Mohamed A Mohamed, Holly J. Murray, Kadee N. Lawrence, Caitlin S. Pepperell
This study evolves Mycobacterium tuberculosis biofilms to examine adaptation mechanisms, finding that genetic variation and mutational biases influence replicability and that some biofilm-associated mutations are common in natural TB infections.
bioRxiv · Jun 7, 2024 · PreprintEvolutionary Biology