Daniel D. Lam

The paper introduces vsdistill, a method for improving power in genomics by distilling variant sets, and demonstrates its effectiveness through simulations and UK Biobank analysis.

The paper shows that MEIS2 and DLX5 activate enhancers for projection neurons, while LHX6 represses them in interneurons, and a MEIS2 mutation linked to intellectual disability impairs this process.

This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.

The paper identifies cell type-specific epigenetic features in a conserved MEIS1 intronic region associated with insomnia and restless legs syndrome, showing their role in MEIS1 regulation.