Genetic and Epigenetic Characterization of Sarcoma Stem Cells Across Subtypes Identifies EZH2 as a Therapeutic Target
Edmond F. O’Donnell, Maria Muñoz, Ryan R. Davis, Jessica Bergonio, Robert Lor Randall, Clifford G. Tepper, Janai R. Carr
The paper identifies EZH2 as a therapeutic target in sarcoma stem cells (STS-CSCs) across subtypes, showing that targeting EZH2 reduces CSC populations and restores chemosensitivity in resistant cell lines.
npj Precision Oncology · Jan 9, 2025Peer-reviewedCancer Biology