Deficiency of Shank3 in the Nucleus Accumbens Reveals a Loss of Social-Specific Motivation
Oakleigh M. Folkes, Meaghan Donahue, Sung Eun Wang, Paola N. Negrón-Moreno, Nicole Xinyen Oo, Sheng-Nan Qiao, Xiaoming Wang, Yong‐hui Jiang
This study shows that reducing Shank3 in the nucleus accumbens decreases social motivation in mice without affecting food reward or anxiety.
Communications Biology · Nov 14, 2025Peer-reviewedNeuroscience