Author

Dilek Coskun

Schrodinger (United States)ORCID 0000-0002-2080-0852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Allan HaldaneiD· 1 shared Edward B. MilleriD· 1 shared Howook Hwang· 1 shared Muyun LihaniD· 1 shared Richard A. FriesneriD· 1 shared Ronald M. LevyiD· 1 shared Vardan H. VardanyaniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Allan HaldaneORCID

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1 paper

Recent·Most cited

Results of a large scale study of the binding of 50 type IIinhibitors to 348 kinases: The role of protein reorganization

Vardan H. Vardanyan, Allan Haldane, Howook Hwang, Dilek Coskun, Muyun Lihan, Edward B. Miller, Richard A. Friesner, Ronald M. Levy

This paper analyzes the binding of 50 type II inhibitors to 348 kinases, showing that protein reorganization significantly contributes to inhibitor selectivity with an AUC of ~0.8.

Journal of Medicinal Chemistry · Apr 9, 2026Peer-reviewedBiophysics