Author

Howook Hwang

Schrodinger (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:machine learning (classical)· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Barry H. HonigiD· 2 shared Aleksandar Obradovic· 1 shared Allan HaldaneiD· 1 shared Brian Estrella· 1 shared Chang Liu· 1 shared Charles KaraniD· 1 shared Deepika Dayal MathuriD· 1 shared Diana MurrayiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Barry H. HonigORCID

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Author profile →

3 papers

Recent·Most cited

Results of a large scale study of the binding of 50 type IIinhibitors to 348 kinases: The role of protein reorganization

Vardan H. Vardanyan, Allan Haldane, Howook Hwang, Dilek Coskun, Muyun Lihan, Edward B. Miller, Richard A. Friesner, Ronald M. Levy

This paper analyzes the binding of 50 type II inhibitors to 348 kinases, showing that protein reorganization significantly contributes to inhibitor selectivity with an AUC of ~0.8.

Journal of Medicinal Chemistry · Apr 9, 2026Peer-reviewedBiophysics

A Novel CREBBP/p300 Activator, YF2, Enhances Cytotoxic and Immune-Mediated Responses in B-Cell Lymphoma

Ted B. Piorczynski, Yuxuan Liu, Brian Estrella, Edd Ricker, Manuel Pazos, Yulissa Gonzalez, Seda Serra Tolu, Yun Kyoung Tiger, Aleksandar Obradovic, Chang Liu, Charles Karan, Serge Cremers, Renu Nandakumar, Barry H. Honig, Howook Hwang, , Jennifer Effie Amengual

This paper evaluates YF2, a CREBBP/p300 activator, showing it enhances cytotoxicity and immune responses in B-cell lymphoma by restoring acetylation and altering the immune microenvironment.

bioRxiv · Mar 13, 2025 · PreprintCancer Biology

PrePCI: A structure- and chemical similarity-informed database of predicted protein compound interactions

Stephen J. Trudeau, Howook Hwang, Deepika Dayal Mathur, Kamrun Begum, Donald S. Petrey, Diana Murray, Barry H. Honig

PrePCI predicts protein-compound interactions using structural and chemical similarity, providing a database of over 5 billion interactions with associated probabilities.

Protein Science · Feb 13, 2023Peer-reviewedSystems Biology