Author

Bryan T. MacDonald

Broad InstituteORCID 0000-0002-2090-2066Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandro ArduiniiD· 1 shared Bidur Bhandary· 1 shared Charles C. MundorffiD· 1 shared Daniel LaiiD· 1 shared Dylan Laprise· 1 shared Harrison SpechtiD· 1 shared Hasmik KeshishianiD· 1 shared Hilary K. FinucaneiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Alessandro ArduiniORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineScience AdvancesPeer-reviewedApr 22, 2022

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways

Zhi Yu, Seyedeh Maryam Zekavat, Sara Haidermota…·Pradeep Natarajan

This study identifies shared immune pathways between coronary artery disease and pneumonia through genome-wide pleiotropy analysis, highlighting ADAMTS7 and IL6R as key genes with opposing effects on the two conditions.

11 citations

humanGWAS summary statistics

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Molecular BiologyMolecular & Cellular ProteomicsPeer-reviewedMar 10, 2022

TAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease

Bryan T. MacDonald, Hasmik Keshishian, Charles C. Mundorff…·Patrick T. Ellinor

The paper identifies ADAMTS7 substrates and cleavage sites using TAILS, revealing potential biomarkers for coronary artery disease.

22 citations

mouseproteomics

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