Cancer BiologySciencePeer-reviewed
Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2
Joseph E. Klebba, Nilotpal Roy, Steffen M. Bernard…·Matthew P. Patricelli
The paper develops covalent inhibitors targeting the RAS binding domain of PI3Kα, showing efficacy against RAS and HER2-driven tumors without affecting glucose homeostasis.
16 citationstop 4%