Johnathan Abou‐Fadel

Whole-genome Omics delineates the function of CCM1 within the CmPn networks

The paper investigates CCM1's role in CmPn signaling networks using omics and systems biology analysis in mouse models, finding it regulates gene transcription and microvessel integrity.

Blood prognostic biomarker signatures for hemorrhagic cerebral cavernous malformations (CCMs)

The paper identifies blood biomarker signatures associated with hemorrhagic cerebral cavernous malformations through proteomic analysis and pathway enrichment.

CCM signaling complex (CSC) is a master regulator governing homeostasis of progestins and their mediated signaling cascades

The paper identifies the CCM signaling complex (CSC) as a master regulator of progestin homeostasis and signaling, and reports serum biomarkers for predicting hemorrhagic events in CCM pathogenesis.

CCM signaling complex (CSC) coupling both classic and non-classic progesterone receptor signaling

The paper identifies a novel signaling network involving the CCM signaling complex that couples classic and non-classic progesterone receptor pathways, showing how disruptions in this balance may increase breast cancer risk.

Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

The paper analyzes perturbed CCM signaling complex (CSC) using RNA-seq and proteomics to identify downstream signaling pathways and regulatory networks involved in angiogenesis.