Brian I. Grajeda

This study identifies MCM10 as a potential biomarker for CRC disparities in Hispanics by analyzing stress-survival pathway gene expression and functional roles in tumor progression.

The paper investigates CCM1's role in CmPn signaling networks using omics and systems biology analysis in mouse models, finding it regulates gene transcription and microvessel integrity.

The paper identifies blood biomarker signatures associated with hemorrhagic cerebral cavernous malformations through proteomic analysis and pathway enrichment.

The paper characterizes a zebrafish gabra1 loss of function allele, showing decreased mRNA expression and seizure-like phenotypes, supporting previous findings on GABRA1's role in nervous system development.

The paper investigates the effects of different HCFC1 mutations in zebrafish on mTor activity and radial glial cell phenotypes, revealing differential outcomes linked to mutation type.

The paper identifies the CCM signaling complex (CSC) as a master regulator of progestin homeostasis and signaling, and reports serum biomarkers for predicting hemorrhagic events in CCM pathogenesis.

The paper identifies a novel signaling network involving the CCM signaling complex that couples classic and non-classic progesterone receptor pathways, showing how disruptions in this balance may increase breast cancer risk.

The paper analyzes perturbed CCM signaling complex (CSC) using RNA-seq and proteomics to identify downstream signaling pathways and regulatory networks involved in angiogenesis.