Alireza Mashaghi

This study uses UV-induced thymine dimerization to control mechanochemistry and fusion dynamics of biomolecular condensates, revealing how photochemical reactions influence their behavior.

This study investigates how the glucocorticoid receptor and its ligand dexamethasone modulate Nur77-DNA interactions using single-molecule assays, revealing distinct effects on binding dynamics and affinity.

This study uses circuit topology to analyze protein folding, showing that ordered and disordered proteins differ in topological organization and that topology predicts folding state and kinetics.

The paper introduces a PyMOL plugin for analyzing protein circuit topology with a GUI, automatic installation, and integration of existing CT methodologies.

The paper predicts destabilizing tyrosine phosphorylations in cancers using machine learning, finding 58% of recurrent phosphorylations are destabilizing and identifying pathway and network patterns associated with these events.

This study investigates how phosphorylation affects the conformational dynamics of the disordered GR NTD, revealing distinct topological changes and introducing a new analysis framework.

This study creates and characterizes extracellular biomolecular condensates using heparan sulfate to explore their interactions with cells and properties.

This study uses computational modeling to show that polyglutamine expansion in the androgen receptor's N-terminal domain causes dynamic misfolding, altering interdomain interactions and potentially leading to SBMA pathology.

This paper uses scanning probe microscopy to study the mechanical properties of biomolecular condensates, revealing their gelation and rejuvenation processes.

This study correlates the structure of pathogenic and non-pathogenic PABPN1 protein aggregates with cellular function in differentiated muscle cells using multimodal imaging.