Laurens W.H.J. Heling

This study investigates how the glucocorticoid receptor and its ligand dexamethasone modulate Nur77-DNA interactions using single-molecule assays, revealing distinct effects on binding dynamics and affinity.

This study uses computational modeling to show that polyglutamine expansion in the androgen receptor's N-terminal domain causes dynamic misfolding, altering interdomain interactions and potentially leading to SBMA pathology.