Acute social defeat induces cannabinoid type 1 receptor-dependent synaptic depression in the anterior ventral subiculum to anterior hypothalamic nucleus pathway to drive social avoidance in male mice
Changsu Woo, Soonje Lee, Changwoo Lee, Donghyeon Yoon, Sukwoo Choi, Shin Jung Kang, Kyuhyun Choi, Ki Soon Shin
This study identifies a CB1R-dependent synaptic depression in the avSUB->AHN pathway that drives social avoidance in male mice following acute social defeat stress.
bioRxiv · Oct 26, 2026 · PreprintNeuroscience