Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS
Daniel Chen, Polyxeni Philippidou, Bianca de Freitas Brenha, Ashleigh E. Schaffer, Helen C. Miranda
This study develops a human neuromuscular junction model from pluripotent stem cells to investigate synaptic dysfunction in familial ALS and assess therapeutic candidates.
bioRxiv · Jan 11, 2024 · PreprintNeuroscience