Author

Daniel Chen

Case Western Reserve UniversityORCID 0000-0001-6036-5552Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Daniel Chen1 paper · Institute for Systems Biology

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Helen C. MirandaiD· 2 shared Abigail L. BuchwalteriD· 1 shared Ashleigh E. SchafferiD· 1 shared Bianca de Freitas BrenhaiD· 1 shared David W Archer· 1 shared Elizabeth L. WagneriD· 1 shared George T. Hashisaki· 1 shared Jessica MellaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Helen C. MirandaORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 16, 2026

Emerin loss of function inhibits MyoD-driven differentiation of human iPSCs into skeletal myotubes

Tracy A Knight, Jessica Mella, Daniel Chen…·Abigail L. Buchwalter

This study shows that emerin loss impairs MyoD-driven differentiation of human iPSCs into skeletal myotubes by affecting PRC2-mediated gene regulation.

DOI 10.64898/2026.09.14.750687

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJan 11, 2024

Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

Daniel Chen, Polyxeni Philippidou, Bianca de Freitas Brenha…·Helen C. Miranda

This study develops a human neuromuscular junction model from pluripotent stem cells to investigate synaptic dysfunction in familial ALS and assess therapeutic candidates.

3 citations

humanexperimental assay

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NeuroscienceeLifePeer-reviewedMay 18, 2023

Repair of Noise-Induced Damage to Stereocilia F-actin Cores is Facilitated by XIRP2

Elizabeth L. Wagner, Jun‐Sub Im, Stefano Sala…·Jung‐Bum Shin

The paper shows that XIRP2 facilitates repair of noise-induced damage to stereocilia F-actin cores in mouse auditory hair cells by enriching monomeric gamma-actin at damaged sites.

13 citations

mouseexperimental assay

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