Dylan M. Glubb

Genetic analysis of female genital tract polyps implicates genome stability, estrogen signalling and shared susceptibility with proliferative gynaecological disorders

This study identifies 52 genetic risk loci for female genital tract polyps, highlighting shared susceptibility with endometriosis, fibroids, and endometrial cancer through genome-wide association and Mendelian randomisation.

Sex-specific dissection of adiposity genetics reveals distinct pathways to endometrial cancer risk

This study identifies sex-specific genetic links between adiposity and endometrial cancer, revealing distinct biological pathways and shared genetic components.

SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion

The paper introduces SAI-10k-calc, a tool that extends SpliceAI to predict splicing aberrations and their effects, achieving high sensitivity and specificity for variant impact prediction.

Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations

This study combines genome-wide association data from four cancers to identify shared and novel genetic associations and pleiotropic effects.

Analysis of promoter-associated chromatin interactions reveals biologically relevant candidate target genes at endometrial cancer risk loci

The paper identifies candidate target genes at endometrial cancer GWAS risk loci using HiChIP chromatin looping analysis and finds associations between risk variation and gene expression.