Jackson G. Thorp

Dissecting Pleiotropy Between Major Depressive Disorder and Physical Disease Comorbidities

This study identifies genetic pleiotropy between major depressive disorder and four physical disease clusters, finding strong associations with gastrointestinal diseases and uncovering novel biological pathways.

Atypical energy-related symptoms define biologically distinct subtypes of major depressive disorder

The paper identifies biologically distinct subtypes of MDD based on energy-related symptoms and finds genetic and metabolic differences between them.

Sex-specific dissection of adiposity genetics reveals distinct pathways to endometrial cancer risk

This study identifies sex-specific genetic links between adiposity and endometrial cancer, revealing distinct biological pathways and shared genetic components.

Genetic Liability for Internalizing-Externalizing Traits in Mexican Youth: Moderation by Adversity

This study examines genetic and environmental factors influencing mental health disorders in Mexican youth, finding that genetic liabilities and adversity interact to predict internalizing and externalizing traits.

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

This paper introduces GNA, a framework that uses network modeling on GWAS data to identify genetic architecture and trait-specific biology.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Genetic structure of major depression symptoms across clinical and community cohorts

This study identifies genetic subtypes of major depressive symptoms by analyzing data from clinical and community cohorts, finding distinct factors for appetite/weight symptoms and missing data patterns.

Investigating the genetic relationship between depression symptoms and Alzheimer's disease in clinically diagnosed and proxy cases

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

The paper identifies novel genetic risk loci for depression and anxiety using factor analysis and genomic SEM, revealing shared and trait-specific genetic influences.

A systematic analysis of genetically regulated differences in gene expression and the role of co-expression networks across 16 psychiatric disorders and substance use phenotypes

The paper identifies 1,645 genes associated with 16 mental health phenotypes using transcriptome-wide association studies and finds higher transcriptomic correlations than genetic correlations for some phenotype pairs.

Investigating Genetic Heterogeneity in Major Depression Through Item-level Genetic Analyses of the PHQ-9

This study performs item-level genetic analyses of the PHQ-9 to explore genetic heterogeneity in major depression, identifying novel loci and revealing distinct genetic correlations across symptoms.