Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA
Zhidong Zhang, Xuenan Pi, Chang Jian Gao, Jun Zhang, Xia Lin, Xiaoqin Yan, Xinlei Hu, Ziyue Yan, Shuxin Zhang, Ailin Wei, Yuer Guo, Jingfeng Liu, Ang Li, Xiaolong Liu, Wei Zhang, , Dan Xie
The paper develops an integrated model using fragmentomic and 5-hydroxymethylcytosine features from low-pass sequencing data to achieve high sensitivity and specificity in pan-cancer detection.
Translational Oncology · May 18, 2023Peer-reviewedGenetic & Genomic Medicine