Genetic & Genomic MedicineTranslational OncologyPeer-reviewed
Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA
Zhidong Zhang, Xuenan Pi, Chang Jian Gao…·Dan Xie
The paper develops an integrated model using fragmentomic and 5-hydroxymethylcytosine features from low-pass sequencing data to achieve high sensitivity and specificity in pan-cancer detection.