Wei Zhang

Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer Disease

The paper demonstrates the feasibility of detecting methylation differences in serum-derived cell-free DNA between Alzheimer's disease and non-AD controls using LABS, linking these changes to brain-specific epigenetic alterations in AD.

Discovery of circulating cell-free DNA 5hmC biomarkers for peritoneal metastasis in colorectal and appendiceal cancer

This study uses 5hmC-Seal technology to detect 5hmC signatures in cfDNA from plasma, identifying peritoneal metastases in CRC and AA with high sensitivity but moderate specificity.

Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjects

This study uses machine learning to identify 5-hydroxymethylation biomarkers in cell-free DNA that can detect occult colorectal cancer up to 36 months before diagnosis.

Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA

The paper develops an integrated model using fragmentomic and 5-hydroxymethylcytosine features from low-pass sequencing data to achieve high sensitivity and specificity in pan-cancer detection.

Genome-wide Analysis Reflects Novel 5-Hydroxymethylcytosines Implicated in Diabetic Nephropathy

The paper identifies 5-hydroxymethylcytosine (5hmC) modifications associated with diabetic nephropathy using cfDNA and machine learning.