Yasmin Striedner

G-quadruplex structures act as a novel recognition motif for the meiosis-specific histone methyltransferase PRDM9

This study shows PRDM9 binds G-quadruplex structures, enhancing meiotic recombination by creating chromatin accessibility.

Activating mutations in FGFR3 are associated with clonal expansion events and high de novo rates in the male germline

The paper investigates FGFR3 mutations in the male germline, finding some mutations increase with age and lead to clonal expansions and higher mutation rates.

Quantitation of FGFR3 signaling via GRB2 recruitment on micropatterned surfaces

The paper quantifies FGFR3 signaling in live cells using micropatterned surfaces and GRB2 recruitment, showing ligand-dependent and mutant-specific activation patterns.

PRDM9 forms an active trimer mediated by its repetitive zinc finger array

The paper shows PRDM9 forms an active trimer with DNA, mediated by its ZnF array, and identifies which ZnF binds DNA while others stabilize the complex.