Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function
Sameer Ahmed Bhat, Zahra Vasi, Liping Jiang, Shruthi Selvaraj, Rachel Ferguson, Sanaz Salarvand, Anish Gudur, Ritika Adhikari, Veronica Castillo, Hagar Ismail, Avantika Dhabaria, Beatrix M. Ueberheide, Shafi Kuchay
This study identifies how geranylgeranylation of FBXO10 enables its targeting to the outer mitochondrial membrane, where it regulates PGAM5 ubiquitination and mitochondrial function.
Cell Reports · Sep 21, 2024Peer-reviewedCell Biology