Beatrix M. Ueberheide

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

This study identifies molecular factors shaping small RNA content in mouse sperm, revealing dynamics and protein associations during spermiogenesis and capacitation.

The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.

This study identifies 79 cargos bound by IPO9, showing it recognizes proteins without cNLSs, and defines structural elements that mediate cargo selection and release.

The paper uses proteomic profiling to identify molecular changes in Elp1-deficient trigeminal ganglia, revealing disruptions in neurotrophic and metabolic pathways in a familial dysautonomia mouse model.

This study identifies a lineage-specific venom gene family in cephalopods, revealing its evolutionary origin, structural diversity, and glandular localization.

This study uses patient-derived tau aggregates to induce disease-specific tauopathy features in human cells, revealing distinct pathological responses across tau strains.

This paper identifies biomolecules associated with Plasmodium falciparum hemozoin as the key drivers of brain endothelial barrier disruption in cerebral malaria.

This study identifies GMCL1 as a negative regulator of the mitotic stopwatch pathway, showing it promotes 53BP1 degradation and reduces paclitaxel sensitivity in cancer cells.

This study shows that tRNA modification mcm5s2U34 is essential for stress granule formation and melanoma metastasis, suggesting it as a therapeutic target.

This study shows FGL-1 binding to LAG-3 inhibits T cell activation by disrupting CD28 and TCR signaling through Lck mislocalization and reduced phosphorylation.

ImmunoVerse integrates RNA-Seq and immunopeptidomes to catalog 28,446 tumor-specific HLA-presented antigens across 21 cancers, including a splicing-derived PMEL peptide with T cell expansion support.

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

This study identifies how geranylgeranylation of FBXO10 enables its targeting to the outer mitochondrial membrane, where it regulates PGAM5 ubiquitination and mitochondrial function.

This study identifies interaction interfaces between SLC25A46 and mitochondrial fusion proteins Opa1 and Mfn2 using crosslinking mass-spectrometry and AlphaFold 2 modeling.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

The paper shows that synonymous mutations in mycobacteria can create new transcription start sites within genes, leading to smaller protein isoforms.

The paper compiles and analyzes proteomic data from 38 Alzheimer's disease studies to create a database of protein changes in human brain tissue across disease stages and regions, revealing patterns of protein dysfunction.

The paper identifies proteomic differences in epilepsy brain tissue, highlighting altered protein networks in hippocampus, cortex, and dentate gyrus, with GNB1 as a key decreased protein.

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.