The paper identifies endosomal microautophagy (eMI) activation in trout hepatocytes under specific stress conditions and suggests its compensatory role when CMA is impaired.

Scientific Reports · Nov 10, 2025Peer-reviewedCell Biology

Chaperone-Mediated Autophagy in Fish: A Key Function Amid a Changing Environment

Simon Schnebert, Emilio J. Vélez, Maxime Goguet, Karine Dias, Vincent Véron, Isabel García-Pérez, Lisa M. Radler, Emilie Cardona, Stéphanie Fontagné-Dicharry, Pierre Van Delft, Franziska Dittrich-Domergue, Amélie Bernard, Florian Beaumatin, Amaury Herpin, Beth M. Cleveland, Iban Seiliez

This study identifies and validates the CMA activation score in rainbow trout, revealing Lamp2A's role in hepatic proteostasis under nutritional stress.

Autophagy Reports · Nov 1, 2024Peer-reviewedCell Biology

Dissecting the nutritional regulations of a whole amino acid transporter family from a complex genome species: A holistic approach turning weaknesses into strengths

Soizig Le Garrec, Karine Pinel, Cécile Heraud, Akintha Ganot, Vincent Véron, Guillaume Morin, Ophélie Iorfida, Emilie Cardona, Lucie Marandel, Anne Devin, Jacques Labonne, Julien Avérous, Alain Bruhat, Iban Seiliez, Florian Beaumatin

The paper identifies and characterizes the amino acid transporter family in rainbow trout, revealing their regulatory mechanisms and functional roles in amino acid homeostasis.

bioRxiv · Oct 11, 2024 · PreprintCell Biology

The zebrafish as a new model for studying chaperone-mediated autophagy unveils its role in spermatogenesis

Maxime Goguet, Emilio J. Vélez, Simon Schnebert, Karine Dias, Vincent Véron, Alexandra Depincé, Florian Beaumatin, Amaury Herpin, Iban Seiliez

This study establishes zebrafish as a model for studying chaperone-mediated autophagy (CMA), revealing its role in spermatogenesis and tissue-specific variations.

bioRxiv · Jun 10, 2024 · PreprintCell Biology