From GWAS to drug: A framework for drug candidate prioritisation using a gene expression signature matching approach
Solal Chauquet, Jiayue-Clara Jiang, Lauren F. Barker, Zoe L. Hunter, Gagandeep Singh, Naomi R. Wray, Allan F. McRae, Sonia H Shah
This paper benchmarks parameters for TWAS signature-matching to prioritize drug candidates using GWAS data and CMap, showing sensitivity to cell line choice and proposing a best-practice framework.
medRxiv · Jun 24, 2026 · PreprintGenetic & Genomic Medicine