GenomicsGenome MedicinePeer-reviewed
Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition
Tuan Vo, Brad Balderson, Kahli Jones…·Laura A. Genovesi
The paper uses spatial transcriptomics to analyze how CDK4/6 inhibition affects tumor response in SHH medulloblastoma by mapping cellular states and spatial organization.