Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition
Tuan Vo, Brad Balderson, Kahli Jones, Guiyan Ni, Joanna Crawford, Amanda Millar, Elissa Tolson, Matthew Singleton, Onkar Mulay, Shaun B. Walters, Marija Kojic, Thomas Robertson, Dharmesh Dinesh Bhuva, Melissa J. Davis, Brandon J. Wainwright, , Laura A. Genovesi
The paper uses spatial transcriptomics to analyze how CDK4/6 inhibition affects tumor response in SHH medulloblastoma by mapping cellular states and spatial organization.
Genome Medicine · May 1, 2023Peer-reviewedGenomics