Author

Hao Chai

Peking UniversityORCID 0000-0002-2279-891XUnclaimed ORCID profile · follow to get notified of new preprints

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Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Jiachen WeiiD· 1 shared Yi Qin GaoiD· 1 shared Yue XueiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBioinformatics

Jiachen WeiORCID

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1 paper

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BioinformaticsNucleic Acids ResearchPeer-reviewedSep 7, 2026

GenoME: a MoE-based generative model for individualized, multimodal prediction and perturbation of genomic profiles

Jiachen Wei, Yue Xue, Hao Chai, Yi Qin Gao

GenoME predicts genomic profiles and perturbations using ATAC-seq and DNA sequence, generalizing to new cell types and identifying enhancer-promoter connections.

DOI 10.1093/nar/gkag902

ATAC-seqDNA methylation

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