Jiachen Wei

GenoME predicts genomic profiles and perturbations using ATAC-seq and DNA sequence, generalizing to new cell types and identifying enhancer-promoter connections.

This paper introduces RASP, a deep learning model that improves structure prediction with restraints, and FAAST, a pipeline that accelerates NMR NOESY peak assignment and structure ensemble generation.

HiCGen predicts and perturbs chromatin organization, revealing loop domains' role in higher-order structures like TADs and compartments.