MicrobiologybioRxivPreprint
3-Phenylpropionic acid, a microbiota-derived polyphenol metabolite linked to hippuric acid, ameliorates colitis as a colon-enriched PPAR-γ agonist
Liyuan Xiang, Wanrong Luo, Wenjie Zhang…·Yijun Zhu
This study identifies 3-phenylpropionic acid (3-PPA) as a colon-enriched PPAR-γ agonist derived from polyphenol metabolism, which ameliorates colitis in mice and highlights its potential as a microbiota-targeted therapeutic for Crohn's disease.
DOI 10.1101/2025.11.25.690607