Shinobu Hirai

This study shows that restoring GLUT1 in both astrocytes and endothelial cells improves glucose homeostasis and cognitive function in GLUT1 deficiency syndrome.

This study shows that high-sucrose diets in Glo1-deficient mice cause brain angiopathy, impaired glucose uptake, and psychosis-related behaviors, with aspirin offering protection.

This study shows that minocycline prevents early aging phenotypes in Rp58 hetero-KO mice by mitigating DNA damage and cognitive decline.

This study shows that early-life stress accelerates Alzheimer's disease pathology by inducing vascular changes and microglia activation in mice with an APP mutation.