Author
Tokyo Metropolitan Institute of Medical ScienceORCID 0000-0001-7621-6172Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Chika Mochizuki-Ono, Yoshitaka Taketomi, Atsushi Irie…·Makoto Murakami
This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.
Hayato Hirai, Tomohiro Iguchi, Kenji Kitajima…·Hiroyuki Sasanuma
This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.
Akinori Endo, Chikage Takahashi, Naoko Ishibashi…·Yukiko Yoshida
The paper identifies the TAB-TAK1-IKK-NF-κB axis as a ubiquitin-regulated pathway activated by lysosomal damage, promoting cell survival through anti-apoptotic and intercellular signaling genes.
Shinobu Hirai, Hideki Miwa, Tomoko Tanaka…·Haruo Okado
This study shows that high-sucrose diets in Glo1-deficient mice cause brain angiopathy, impaired glucose uptake, and psychosis-related behaviors, with aspirin offering protection.
Tomoko Tanaka, Shinobu Hirai, Hiroyuki Manabe…·Haruo Okado
This study shows that minocycline prevents early aging phenotypes in Rp58 hetero-KO mice by mitigating DNA damage and cognitive decline.