BiochemistrybioRxivPreprint
De novo protein design in an expanded chemical space
Yuxuan Li, Yanbo Jing, Yeyu Su…·Tao Liu
This paper introduces CheMoDesign, a framework for de novo protein design with user-specified chemistry, demonstrating its ability to generate proteins with chemistry-dependent recognition and reactivity.
DOI 10.64898/2026.10.08.757794