Huafu Chen

Individual Brain Structure Deviations and its Gene Expression Signatures in Early-Onset Schizophrenia

This study identifies individual-level brain structure deviations and their gene expression signatures in early-onset schizophrenia, revealing two distinct transcriptomic subtypes associated with different neurodevelopmental processes.

Inflammation in schizophrenia: Peripheral interleukin-6 levels-related disease-specific functional activity abnormalities

The paper identifies an IL-6-related functional brain pattern amplified in schizophrenia, linking peripheral inflammation to network dysregulation.

Neurodevelopmental deviations in schizophrenia: Evidences from multimodal connectome-based brain ages

This study uses multimodal MRI data to estimate brain age in early-onset schizophrenia patients and finds increased brain age gaps correlated with symptom severity.

Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations

This study identifies neurodevelopmentally rooted epicenters of cortical thickness alterations in schizophrenia, linking them to specific functional regions and genetic factors.

Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories

The paper develops population-specific brain charts for Chinese individuals, revealing distinct neurodevelopmental patterns compared to Western populations and showing better performance in predicting brain phenotypes.

Contracted anterior-posterior systematic covariance of cortical thickness in early-onset schizophrenia

This study identifies a contracted anterior-posterior organizational axis of cortical thickness in early-onset schizophrenia using structural MRI data.

Unraveling Integration-Segregation Imbalances in Schizophrenia Through Topological High-Order Functional Connectivity

This study examines topological high-order functional connectivity in schizophrenia, finding disrupted integration-segregation balance and potential diagnostic indicators.

China Autism Brain Imaging Consortium: Charting Brain Growth in Chinese Children with Autism

The paper introduces CABIC, a dataset of MRI scans from Chinese autistic and typically developing children, revealing distinct brain growth patterns and highlighting ethnic and cultural differences in neurodevelopment.

Mother-child dyadic interactions shape children's social brain and theory of mind

The paper examines how age and parental caregiving influence social brain development and Theory of Mind in children through naturalistic fMRI studies of mother-child dyads.

From Sight to Insight: A Multi-task Approach with the Visual Language Decoding Model

This paper introduces a Visual Language Decoding Model (VLDM) that simultaneously decodes visual categories, semantic labels, and textual descriptions from neural data, achieving significant improvements over chance levels.

Macroscale Thalamic Functional Organization Disturbances And Underlying Core Cytoarchitecture In Early-Onset Schizophrenia

This study investigates macroscale thalamic functional organization disturbances and their relation to core cytoarchitecture in early-onset schizophrenia using resting-state fMRI and gene expression data.

IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis

The paper shows IL4-driven Arg1+ microglia restore hippocampal neurogenesis and promote stress resilience by increasing BDNF levels in mice.

Putamen volume predicts real-time fMRI neurofeedback learning success across paradigms and neurofeedback target regions

The paper finds that right putamen gray matter volume predicts success in real-time fMRI neurofeedback training across different paradigms and target regions.

Shared dynamic functional connectivity across schizophrenia, bipolar disorder and major depressive disorder

This study identifies shared dynamic functional connectivity patterns across schizophrenia, bipolar disorder, and major depressive disorder, highlighting state-dependent dysconnectivity in specific brain networks.