Probing recombinant AAV capsid integrity and genome release under thermal stress by single-molecule interferometric scattering microscopy
Eduard H.T.M. Ebberink, Alisa Ruisinger, Markus Nuebel, Helena Meyer‐Berg, Irene R.S. Ferreira, Marco Thomann, Albert J. R. Heck
This study uses single-molecule interferometric scattering microscopy to analyze AAV capsid stability and genome release under thermal stress, revealing AAV-specific uncoating behaviors.
Molecular Therapy — Methods & Clinical Development · Jun 24, 2024Peer-reviewedBiophysics