The amino acid residue in position 163 of canine PrPC is critical to the exceptional resistance of dogs to prion infections: evidence from transgenic mouse models
Enríc Vidal, Natalia Fernández‐Borges, Hasier Eraña, Beatriz Parra, Belén Pintado, Manuel Sánchez‐Martín, Jorge M. Charco, Montserrat Ordóñez, Miguel A. Pérez‐Castro, Martí Batlle Pumarola, Candace K. Mathiason, Tomás Mayoral, Joaquı́n Castilla
The paper shows that a specific amino acid at position 163 in canine PrPC confers resistance to prion infection, confirmed through transgenic mouse models.
bioRxiv · Oct 10, 2019 · PreprintNeuroscience