Joaquı́n Castilla

This study investigates the early unfolding events of the E200K mutant prion protein in bank voles, comparing it to the wild-type protein to understand its enhanced capacity to generate PrPSc.

This paper demonstrates that the G127V prion protein variant can prevent and suppress prion infection through a dominant-negative effect, suggesting its potential as a therapeutic strategy.

The paper identifies BMP signaling as a regulator of prion uptake by screening for genetic modifiers in human cells and shows that modulating BMP components affects prion internalization.

The paper investigates the early steps of PrPC unfolding during PrPSc propagation using NMR and simulations, identifying key regions and mechanisms of unfolding/refolding.

The paper shows that a specific amino acid at position 163 in canine PrPC confers resistance to prion infection, confirmed through transgenic mouse models.