Costanza Emanueli

Interleukin 11-induced microRNAs as functional mediators and circulating biomarkers of cardiac fibrosis

This study identifies miRNA-27b-5p and miRNA-497-5p as downstream effectors of IL-11-induced cardiac fibrosis and potential circulating biomarkers in aortic stenosis.

Human left ventricle circRNA-miRNA-mRNA network analyses reveals a novel proangiogenic role for circNPHP1 under ischemic conditions

This study identifies a circRNA-miRNA-mRNA network in ischemic heart disease, revealing circNPHP1's role in enhancing angiogenesis by sponging miR-221-3p to upregulate VEGF-A and BCL2.

Multi-response Mendelian randomization: Identification of shared and distinct exposures for multimorbidity and multiple related disease outcomes

This paper introduces Multi-response Mendelian randomization (MR2) to identify shared and distinct exposures for multiple disease outcomes, showing improved power and accuracy by accounting for residual correlations between outcomes.