Julia Gorelik

This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.

This study identifies miRNA-27b-5p and miRNA-497-5p as downstream effectors of IL-11-induced cardiac fibrosis and potential circulating biomarkers in aortic stenosis.

This study investigates how nucleoli drive nuclear remodelling in cardiomyocytes during heart failure, showing NI loss precedes cytoskeletal stiffening and is linked to DNA damage and nucleolar changes.

This study measures how T-tubule structure in cardiomyocytes changes under diastolic stretch, showing shifts, diameter increase, and stiffness.

This paper develops a nanopore-based assay with machine learning for label-free miRNA detection, showing that a CNN outperforms traditional methods in sensitivity and classification.

This paper identifies a nanodomain mechanism regulating troponin I phosphorylation and demonstrates a peptide that selectively enhances relaxation without compromising systolic function in heart failure.

This paper introduces a combined SICM-OPM system for simultaneous non-contact topographical and volumetric fluorescence imaging in live cells, demonstrating its use in studying cellular remodeling and molecular delivery.

This study shows that CASK depletion improves intercalated disc organization and ventricular function in multiple models, suggesting CASK as a repressor of ID structure and function in cardiac disease.