Alexander Haglund

The paper identifies trimodal QTLs that jointly affect enhancer accessibility, promoter contacts, and gene expression in monocytes, revealing genetic links between enhancer activity and chromatin boundaries.

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

This paper introduces Multi-response Mendelian randomization (MR2) to identify shared and distinct exposures for multiple disease outcomes, showing improved power and accuracy by accounting for residual correlations between outcomes.