Khalid Sossey‐Alaoui

The small molecule inhibitor SU056-mediated targeting of YB1 inhibits the Rb pathway in triple-negative breast cancer tumors

This study shows that SU056, a YB1 inhibitor, suppresses TNBC growth and metastasis by targeting the Rb pathway, with enhanced efficacy when combined with CDK4/6 inhibition.

Nuclear translocation of phosphorylated YB-1 via small extracellular vesicles contributes to the malignant phenotype of triple negative breast cancer

This study shows that phosphorylated YB-1 in small extracellular vesicles promotes metastasis in TNBC by translocating to the nucleus of recipient cells.