Echinocandins have an alternative mode of action on biomimetic membranes that is not directly related to the functioning of (1,3) beta-glucan synthase
Anna I. Malykhina, Svetlana S. Efimova, Ekaterina V. Vodopyanova, Natalia E. Grammatikova, Anna N. Tevyashova, Andrey Egorovich Shchekotikhin, Olga S. Ostroumova
This study shows echinocandins form ion-permeable pores in sterol-containing membranes, altering lipid microenvironment and membrane permeability, independent of (1,3) beta-glucan synthase inhibition.
Cell Death Discovery · Apr 28, 2026Peer-reviewedMicrobiology