Author

Daniel Lazarev

Broad InstituteORCID 0000-0002-2445-6809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:statistical model· 2 Approach:diffusion model· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Research Focus:trajectory inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Grant ChauiD· 2 shared Alex Bloemendal· 1 shared Anna SappingtoniD· 1 shared Benjamin M. NealeiD· 1 shared Bonnie BergeriD· 1 shared Claire L. ChurchhouseiD· 1 shared Ruochi ZhangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersBioinformatics

Grant ChauORCID

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2 papers

Recent·Most cited

Constrained Diffusion as a Paradigm for Evolution

Daniel Lazarev, Anna Sappington, Grant Chau, Ruochi Zhang, Bonnie Berger

This paper introduces DiffEvol, a constrained diffusion framework to model evolution, and applies it to SARS-CoV-2 data to reconstruct fitness trends and vaccine-induced phase transitions.

bioRxiv · Mar 16, 2026 · PreprintBioinformatics

GUIDE deconstructs genetic architectures using association studies

Daniel Lazarev, Grant Chau, Alex Bloemendal, Claire L. Churchhouse, Benjamin M. Neale

This paper introduces GUIDE, a method to identify latent genetic factors from GWAS data, revealing biological pathways and environmental influences in complex traits.

bioRxiv · May 3, 2024 · PreprintGenetics