Grant Chau

This paper introduces DiffEvol, a constrained diffusion framework to model evolution, and applies it to SARS-CoV-2 data to reconstruct fitness trends and vaccine-induced phase transitions.

The paper investigates the mechanism of age-related mtDNA mutation accumulation in human blood using whole genome sequences, revealing a two-step process involving cryptic mutations and clonal expansion.

SAIGE-QTL is a tool for single-cell eQTL analysis that directly maps eQTLs without pseudobulk aggregation and improves power for detecting rare variants.

This paper introduces GUIDE, a method to identify latent genetic factors from GWAS data, revealing biological pathways and environmental influences in complex traits.