Anna Sappington

This paper introduces DiffEvol, a constrained diffusion framework to model evolution, and applies it to SARS-CoV-2 data to reconstruct fitness trends and vaccine-induced phase transitions.

This paper develops a new mathematical framework, ProP Gen, to model evolutionary dynamics under phenotypic uncertainty and shows it explains phenomena like phenotypic buoying and improves predictions of bacterial persistence.

This paper introduces ProDiT, a multimodal diffusion model for generating functional proteins with multiple states, demonstrating its ability to design proteins with specific molecular functions and allosteric regulation.

The paper classifies zebrafish retinal ganglion cells using single-cell transcriptomics, identifies marker genes, and links molecular profiles to functional behaviors.

The paper introduces a method to estimate genome containment in metagenomes and applies it to identify a novel polyomavirus.

The paper classifies and compares cell types in primate fovea and peripheral retina using single-cell RNA-seq, finding conserved and divergent features across species and regions.