Author

Leyou Zhang

Google (United States)ORCID 0000-0002-2454-0082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:transformer / foundation model· 1

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Alexander E. Johnson-BuckiD· 1 shared Jieming LiiD· 1 shared Nils G. WalteriD· 1 shared

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2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Alexander E. Johnson-BuckORCID

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1 paper

Recent·Most cited

BiophysicsNature MethodsPeer-reviewedOct 1, 2025

Foundation model for efficient biological discovery in single-molecule data

Jieming Li, Leyou Zhang, Alexander E. Johnson-Buck, Nils G. Walter

The paper introduces META-SiM, a transformer-based model for analyzing single-molecule fluorescence microscopy data, and discovers a new intermediate state in pre-mRNA splicing.

10 citations

fluorescence / live-cell microscopydeep learning

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