Alexander E. Johnson-Buck

PINPOINT provides non-destructive single-particle analysis of lipid nanoparticles and their mRNA cargo, revealing heterogeneity not detectable by bulk methods.

FINDER enables attomolar biomarker detection by converting kinetic fingerprinting into area-scalable sensitivity without amplification.

The paper develops a model to explain miRNA-guided silencing by showing distinct RISC conformations and their roles in target recognition.

The paper introduces META-SiM, a transformer-based model for analyzing single-molecule fluorescence microscopy data, and discovers a new intermediate state in pre-mRNA splicing.

This paper develops an amplification-free method to quantify DNA methylation at the BCAT1 promoter with high sensitivity and specificity, enabling improved early detection of methylated cancer DNA biomarkers.

This study measures MBD1 binding kinetics to methylated DNA with varying patterns and structural motifs, revealing that tandem CpG sites and DNA forks enhance binding, leading to a mechanistic model of epigenetic boundary maintenance.